I’ve been drawn to the biohacking and self-experimentation space since I heard about the guy who got a novel prize for infecting himself with H. Pylori just so he could treat it as proof of his theory of peptic ulcer formation. First, because it’s practical. Self-experimentation isn’t externally valid. I.e., the results aren’t necessarily applicable to others. But they are, by definition, highly relevant to you! The ‘n’ equals ‘1’, but that ‘1’ is the only one that matters. Population statistics don’t apply to individuals. If an intervention does not improve something at a population level but dramatically improve mental well-being in you specifically, that is good information to know!